This is an old revision of the document!
Jhih-Siang (Sean) Lai
Education and Training
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<td width=137 valign=top style='width:136.85pt;border:none;border-bottom: solid #BFBFBF 1.0pt;padding:0cm 5.4pt 0cm 5.4pt'> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Jan 2016—</span></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>present</span></p> </td> <td width=260 valign=top style='width:260.05pt;border:none;border-bottom: solid #BFBFBF 1.0pt;padding:0cm 5.4pt 0cm 5.4pt'> <p class=MsoNormal><b><span lang=EN-GB style='font-size:10.0pt;font-family: "Helvetica",sans-serif'>The University of Queensland</span></b></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>School of Chemistry & Molecular Biosciences PhD</span></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Brisbane, Australia
</span></p>
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<td width=137 valign=top style='width:136.85pt;border:none;border-bottom: solid #BFBFBF 1.0pt;padding:0cm 5.4pt 0cm 5.4pt'> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Sep 2006—</span></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Jun 2009</span></p> </td> <td width=260 valign=top style='width:260.05pt;border:none;border-bottom: solid #BFBFBF 1.0pt;padding:0cm 5.4pt 0cm 5.4pt'> <p class=MsoNormal><b><span lang=EN-GB style='font-size:10.0pt;font-family: "Helvetica",sans-serif'>National Taiwan University</span></b></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Biomedical Engineering MSs</span></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Taipei, Taiwan
</span></p>
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<td width=137 valign=top style='width:136.85pt;border:none;padding:0cm 5.4pt 0cm 5.4pt'> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Sep 2001—</span></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Jun 2006</span></p> </td> <td width=260 valign=top style='width:260.05pt;border:none;padding:0cm 5.4pt 0cm 5.4pt'> <p class=MsoNormal><b><span lang=EN-GB style='font-size:10.0pt;font-family: "Helvetica",sans-serif'>National Chung Cheng University</span></b></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Computer Science and Information Engineering BSc</span></p> <p class=MsoNormal><span lang=EN-GB style='font-size:10.0pt;font-family:"Helvetica",sans-serif'>Chiayi, Taiwan
</span></p>
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Research experience
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</span></p>
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<p class=MsoNormal><span lang=EN-US style='font-size:8.0pt;font-family:"Helvetica",sans-serif'> </span></p> </div> </body> </html>
Publications
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<tr id="Horsefield793" class="entry">
<td>Horsefield S, Burdett H, Zhang X, Manik MK, Shi Y, Chen J, Qi T, Gilley J, Lai J-S, Rank MX, Casey LW, Gu W, Ericsson DJ, Foley G, Hughes RO, Bosanac T, von Itzstein M, Rathjen JP, Nanson JD, Boden M, Dry IB, Williams SJ, Staskawicz BJ, Coleman MP, Ve T, Dodds PN and Kobe B (2019), <i>"NAD+ cleavage activity by animal and plant TIR domains in cell death pathways"</i>, Science. Vol. 365(6455), pp. 793-799. American Association for the Advancement of Science.
<p class="infolinks">[<a href="javascript:toggleInfo('Horsefield793','abstract')">Abstract</a>] [<a href="javascript:toggleInfo('Horsefield793','bibtex')">BibTeX</a>] [<a href="https://doi.org/10.1126/science.aax1911" target="_blank">DOI</a>] [<a href="https://science.sciencemag.org/content/365/6455/793" target="_blank">URL</a>]</p>
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<tr id="abs_Horsefield793" class="abstract noshow">
<td><b>Abstract</b>: One way that plants respond to pathogen infection is by sacrificing the infected cells. The nucleotide-binding leucine-rich repeat immune receptors responsible for this hypersensitive response carry Toll/interleukin-1 receptor (TIR) domains. In two papers, Horsefield et al. and Wan et al. report that these TIR domains cleave the metabolic cofactor nicotinamide adenine dinucleotide (NAD+) as part of their cell-death signaling in response to pathogens. Similar signaling links mammalian TIR-containing proteins to NAD+ depletion during Wallerian degeneration of neurons.Science, this issue p. 793, p. 799SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD+) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related Toll/interleukin-1 receptor (TIR) domains in these proteins, which, as we show, feature self-association–dependent NAD+ cleavage activity associated with cell death signaling. We further show that SARM1 SAM (sterile alpha motif) domains form an octamer essential for axon degeneration that contributes to TIR domain enzymatic activity. The crystal structures of ribose and NADP+ (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and plant NLR RUN1 TIR domains, respectively, reveal a conserved substrate binding site. NAD+ cleavage by TIR domains is therefore a conserved feature of animal and plant cell death signaling pathways.</td>
</tr>
<tr id="bib_Horsefield793" class="bibtex noshow">
<td><b>BibTeX</b>:
<pre>
@article{Horsefield793,
author = {Horsefield, Shane and Burdett, Hayden and Zhang, Xiaoxiao and Manik, Mohammad K. and Shi, Yun and Chen, Jian and Qi, Tiancong and Gilley, Jonathan and Lai, Jhih-Siang and Rank, Maxwell X. and Casey, Lachlan W. and Gu, Weixi and Ericsson, Daniel J. and Foley, Gabriel and Hughes, Robert O. and Bosanac, Todd and von Itzstein, Mark and Rathjen, John P. and Nanson, Jeffrey D. and Boden, Mikael and Dry, Ian B. and Williams, Simon J. and Staskawicz, Brian J. and Coleman, Michael P. and Ve, Thomas and Dodds, Peter N. and Kobe, Bostjan},
title = {NAD+ cleavage activity by animal and plant TIR domains in cell death pathways},
journal = {Science},
publisher = {American Association for the Advancement of Science},
year = {2019},
volume = {365},
number = {6455},
pages = {793–799},
url = {https://science.sciencemag.org/content/365/6455/793},
doi = {10.1126/science.aax1911}
}
</pre></td>
</tr>
<tr id="Lai2013" class="entry">
<td>Lai J-S, Cheng C-W, Lo A, Sung T-Y and Hsu W-L (2013), <i>"Lipid exposure prediction enhances the inference of rotational angles of transmembrane helices"</i>, BMC Bioinformatics. Vol. 14(1)
<p class="infolinks"> [<a href="javascript:toggleInfo('Lai2013','bibtex')">BibTeX</a>] [<a href="http://doi.org/10.1186/1471-2105-14-304" target="_blank">DOI</a>] [<a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885364728&doi=10.1186%2f1471-2105-14-304&partnerID=40&md5=94a3657cd116bd7d03b6986dc049679e" target="_blank">URL</a>]</p>
</td>
</tr>
<tr id="bib_Lai2013" class="bibtex noshow">
<td><b>BibTeX</b>:
<pre>
@article{Lai2013,
author = {Lai, J.-S. and Cheng, C.-W. and Lo, A. and Sung, T.-Y. and Hsu, W.-L.},
title = {Lipid exposure prediction enhances the inference of rotational angles of transmembrane helices},
journal = {BMC Bioinformatics},
year = {2013},
volume = {14},
number = {1},
note = {cited By 4},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84885364728&doi=10.1186%2f1471-2105-14-304&partnerID=40&md5=94a3657cd116bd7d03b6986dc049679e},
doi = {10.1186/1471-2105-14-304}
}
</pre></td>
</tr>
<tr id="Lai2012" class="entry">
<td>Lai J-S, Cheng C-W, Sung T-Y and Hsu W-L (2012), <i>"Computational comparative study of tuberculosis proteomes using a model learned from signal peptide structures"</i>, PLoS ONE. Vol. 7(4)
<p class="infolinks"> [<a href="javascript:toggleInfo('Lai2012','bibtex')">BibTeX</a>] [<a href="http://doi.org/10.1371/journal.pone.0035018" target="_blank">DOI</a>] [<a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859501651&doi=10.1371%2fjournal.pone.0035018&partnerID=40&md5=7214963fdc841e789c68ea476b82b25e" target="_blank">URL</a>]</p>
</td>
</tr>
<tr id="bib_Lai2012" class="bibtex noshow">
<td><b>BibTeX</b>:
<pre>
@article{Lai2012,
author = {Lai, J.-S. and Cheng, C.-W. and Sung, T.-Y. and Hsu, W.-L.},
title = {Computational comparative study of tuberculosis proteomes using a model learned from signal peptide structures},
journal = {PLoS ONE},
year = {2012},
volume = {7},
number = {4},
note = {cited By 5},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-84859501651&doi=10.1371%2fjournal.pone.0035018&partnerID=40&md5=7214963fdc841e789c68ea476b82b25e},
doi = {10.1371/journal.pone.0035018}
}
</pre></td>
</tr>
<tr id="Tsai2009171" class="entry">
<td>Tsai K-N, Lin S-H, Shih S-R, Lai J-S and Chen C-M (2009), <i>"Genomic splice site prediction algorithm based on nucleotide sequence pattern for RNA viruses"</i>, Computational Biology and Chemistry. Vol. 33(2), pp. 171-175.
<p class="infolinks"> [<a href="javascript:toggleInfo('Tsai2009171','bibtex')">BibTeX</a>] [<a href="http://doi.org/10.1016/j.compbiolchem.2008.08.002" target="_blank">DOI</a>] [<a href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-60849120742&doi=10.1016%2fj.compbiolchem.2008.08.002&partnerID=40&md5=f6904c4bcc6c3db6da88433a8436c8c5" target="_blank">URL</a>]</p>
</td>
</tr>
<tr id="bib_Tsai2009171" class="bibtex noshow">
<td><b>BibTeX</b>:
<pre>
@article{Tsai2009171,
author = {Tsai, K.-N. and Lin, S.-H. and Shih, S.-R. and Lai, J.-S. and Chen, C.-M.},
title = {Genomic splice site prediction algorithm based on nucleotide sequence pattern for RNA viruses},
journal = {Computational Biology and Chemistry},
year = {2009},
volume = {33},
number = {2},
pages = {171-175},
note = {cited By 7},
url = {https://www.scopus.com/inward/record.uri?eid=2-s2.0-60849120742&doi=10.1016%2fj.compbiolchem.2008.08.002&partnerID=40&md5=f6904c4bcc6c3db6da88433a8436c8c5},
doi = {10.1016/j.compbiolchem.2008.08.002}
}
</pre></td>
</tr>
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<p class=MsoNormal style='text-align:justify'><a name="_GoBack"></a><b><span
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solid windowtext 1.0pt;padding:0cm 5.4pt 0cm 5.4pt;height:19.85pt'>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:Helvetica'>Year</span></b></p>
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<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:Helvetica'>Description</span></b></p>
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<tr style='height:19.85pt'>
<td width="37%" valign=top style='width:37.74%;border:none;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal style='text-align:justify'><span lang=EN-US
style='font-size:11.0pt;font-family:Helvetica'>Candidate travel award</span></p>
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<td width="12%" valign=top style='width:12.58%;border:none;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:11.0pt;font-family:Helvetica'>2019</span></p>
</td>
<td width="49%" valign=top style='width:49.68%;border:none;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:11.0pt;font-family:Helvetica'>Scholarship
support for 6-month visiting Technische Universität München, Germany (January-July 2019).</span></p>
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</tr>
<tr style='height:19.85pt'>
<td width="37%" valign=top style='width:37.74%;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal style='text-align:justify'><span lang=EN-US
style='font-size:11.0pt;font-family:Helvetica'>University of Queensland
International Scholarship (UQI)</span></p>
</td>
<td width="12%" valign=top style='width:12.58%;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:11.0pt;font-family:Helvetica'>2016</span></p>
</td>
<td width="49%" valign=top style='width:49.68%;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:11.0pt;font-family:Helvetica'>Tuition
fee award for three years</span></p>
</td>
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<tr style='height:19.85pt'>
<td width="37%" valign=top style='width:37.74%;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal style='text-align:justify'><span lang=EN-US
style='font-size:11.0pt;font-family:Helvetica'>Research Higher Degree
Scholarship</span></p>
</td>
<td width="12%" valign=top style='width:12.58%;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:11.0pt;font-family:Helvetica'>2016</span></p>
</td>
<td width="49%" valign=top style='width:49.68%;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:11.0pt;font-family:Helvetica'>Living
cost support for three years</span></p>
</td>
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<p class=MsoNormal><span style='font-family:Helvetica;color:white'> </span></p>
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==== Conferences ====
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<tr style='height:19.85pt'>
<td width=230 valign=top style='width:172.25pt;border:none;border-bottom:
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<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:Helvetica'>Conference name</span></b></p>
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<td width=423 valign=top style='width:317.2pt;border:none;border-bottom:solid windowtext 1.0pt;
padding:0cm 5.4pt 0cm 5.4pt;height:19.85pt'>
<p class=MsoNormal><b><span style='font-size:10.0pt;font-family:Helvetica'>Presentation</span></b></p>
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</tr>
<tr style='height:19.85pt'>
<td width=230 valign=top style='width:172.25pt;border:none;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:10.0pt;font-family:Helvetica'>2019.
ISMB<br>
(Intelligent Systems for Molecular Biology)</span></p>
</td>
<td width=423 valign=top style='width:317.2pt;border:none;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span
style='font-size:10.0pt;font-family:Helvetica'>Phylogenetic analysis in the
predicted secondary structure space (poster)</span></p>
</td>
</tr>
<tr style='height:19.85pt'>
<td width=230 valign=top style='width:172.25pt;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:10.0pt;font-family:Helvetica'>2017.
ISMB<br>
(Intelligent Systems for Molecular Biology)</span></p>
</td>
<td width=423 valign=top style='width:317.2pt;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span
style='font-size:10.0pt;font-family:Helvetica'>Modelling the evolution of
protein secondary structure (poster)</span></p>
</td>
</tr>
<tr style='height:19.85pt'>
<td width=230 valign=top style='width:172.25pt;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal><span lang=EN-US style='font-size:10.0pt;font-family:Helvetica'>2014.
CASP<br>
(Critical Assessment of Structure Prediction)</span></p>
</td>
<td width=423 valign=top style='width:317.2pt;padding:0cm 5.4pt 0cm 5.4pt;
height:19.85pt'>
<p class=MsoNormal style='text-align:justify;text-justify:inter-ideograph'><span
style='font-size:10.0pt;font-family:Helvetica'>Protein residue-residue
contact prediction by co-evolution analysis and machine Learning</span><span
lang=EN-US style='font-size:10.0pt;font-family:Helvetica'> (</span><span
style='font-size:10.0pt;font-family:Helvetica'>poster)</span></p>
</td>
</tr>
</table>
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—-
==== Programming skills ====
JAVA, C/C++, MATALB, R, PYTHON
—-
==== External links ====
Sean in ResearchGate
Sean in ORCID
—-
==== Other skills ====
Certified lifeguard
Trail/Distance running