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research:start [2022/07/26 09:34] – mikael | research:start [2024/03/17 12:38] (current) – mikael | ||
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[[publications|Publications]] | [[publications|Publications]] | ||
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+ | ==== Invited talks ==== | ||
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+ | ASR symposium @ UNSW Sydney 23 Mar 2023 | ||
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+ | [[https:// | ||
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+ | [[https:// | ||
==== Funded Projects ==== | ==== Funded Projects ==== | ||
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+ | **TRIAGE: A disease agnostic computational and modelling platform to accelerate variant classification | ||
+ | (Palpant, Yanes, Stark, Ingles, Harvey, McGaughran, Fatkin, Atherton, Hill, Bodén, Mallett, Bagnall, Shah, Coombes, Richardson) (Medical Research Future Fund 2021 Genomics Health Futures Mission; Dec 2022 - 2025)** | ||
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+ | Over a third of all patients with genetic testing do not have a known cause of disease. This research program implements new methods to reveal genes that are the likely cause of disease. We couple these predictions with disease-agnostic modelling to determine whether specific disease variants identified in patients are the cause of disease. Collectively, | ||
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+ | **What drives the Anterior Expansion of the Central Nervous System? (Thor, Piper, Bodén) (Australian Research Council Discovery Project 230101750; Jan 2023-Dec 2025)** | ||
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+ | A striking and highly conserved feature of the central nervous system is that the brain is larger than the spinal cord. Despite the manifest implications this has for nervous system function, the underlying drivers are largely unknown. This project aims to investigate the mechanisms controlling anterior expansion of the central nervous system, and will generate new knowledge in the areas of nervous system development and evolution. This project aims to impact on our understanding of nervous system function, develop bioinformatics tools with broad utility within the biosciences field, strengthen Australia’s international standing in the developmental neuroscience, | ||
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+ | **What is the common factor driving brain overgrowth in autism? Investigating the relationship between epigenetic marks and neural stem cell proliferation (Piper, Thor, Bodén) (The Simons Foundation Autism Research Initiative 2022 Pilot Award; 2022 - 2024)** | ||
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+ | We will analyze how methylation of H3K36 regulates neural development, | ||
**Dual-function ribonucleases: | **Dual-function ribonucleases: | ||
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* [[research: | * [[research: | ||
* [[research: | * [[research: | ||
- | | + | * Sanjana Tule, PhD student/Research assistant |
- | * [[research: | + | |
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* [[research: | * [[research: | ||
- | * Oliver Hughes, | + | * Oliver Hughes, |
- | * William Rieger, Research assistant | + | * Zachary Riedlshah, PhD student |
- | * Sebastian Porras, Research | + | * Ruyi Chen, PhD student |
+ | * Claire Cheng, visiting | ||
+ | * Sebastian Porras, | ||
+ | * Chongting Zhao, Master student | ||
+ | * Georgia Wyldbore, Master student | ||
+ | * Harry Newton, Master student | ||
+ | * Aishwarya Dhruva, Master student | ||
+ | * William Rieger, visiting from FU Berlin | ||
+ | |||
+ | {{: | ||
+ | |||
+ | //The group anno 2023 (Nov). From left: Linh, Ruyi, Olly, Gabe, Mikael, Sam, Seb, Chongting, Zach, Sanjana// | ||
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+ | {{: | ||
+ | |||
+ | //The new lab contingent of USA Nov 2023. From left: Ariane, Brad// | ||
+ | |||
+ | {{: | ||
+ | |||
+ | //The group anno 2023 (Oct). From left: Gabe, Mikael, Olly, Linh, Seb, Sanjana, Will, Ruyi, Brad// | ||
+ | |||
+ | {{: | ||
+ | |||
+ | //The group anno 2021. From left: Brad, Ariane, Gabe, Sam, Mikael, Rich. In the background: Phaedra, Kieran// | ||
{{: | {{: | ||
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==== Alumni ==== | ==== Alumni ==== | ||
+ | * Thuy Linh Nguyen, Master student | ||
+ | * [[Ariane Mora]], PhD student, now Postdoc at CalTech [[http:// | ||
+ | * [[research: | ||
+ | * William Rieger, Research assistant, now at FU Berlin | ||
* Sorelle Bowman, Master student | * Sorelle Bowman, Master student | ||
* Anoushka Shah, Master student | * Anoushka Shah, Master student |