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research:start [2022/06/05 10:21] – samuelresearch:start [2024/03/17 12:38] (current) – mikael
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 [[publications|Publications]] [[publications|Publications]]
 +
 +==== Invited talks ====
 +
 +ASR symposium @ UNSW Sydney 23 Mar 2023
 +
 +[[https://groups.oist.jp/ldpe|Library Design for Protein Engineering @ Okinawa, Japan 6-9 Nov 2023]]
 +
 +[[https://incob.apbionet.org/incob23/|International Conference on Bioinformatics 12-15 Nov 2023]]
  
 ==== Funded Projects ==== ==== Funded Projects ====
 +
 +**TRIAGE: A disease agnostic computational and modelling platform to accelerate variant classification
 +(Palpant, Yanes, Stark, Ingles, Harvey, McGaughran, Fatkin, Atherton, Hill, Bodén, Mallett, Bagnall, Shah, Coombes, Richardson) (Medical Research Future Fund 2021 Genomics Health Futures Mission; Dec 2022 - 2025)**
 +
 +Over a third of all patients with genetic testing do not have a known cause of disease. This research program implements new methods to reveal genes that are the likely cause of disease. We couple these predictions with disease-agnostic modelling to determine whether specific disease variants identified in patients are the cause of disease. Collectively, these approaches will facilitate accelerated classification of disease causing variants for any disease.
 +
 +**What drives the Anterior Expansion of the Central Nervous System? (Thor, Piper, Bodén) (Australian Research Council Discovery Project 230101750; Jan 2023-Dec 2025)**
 +
 +A striking and highly conserved feature of the central nervous system is that the brain is larger than the spinal cord. Despite the manifest implications this has for nervous system function, the underlying drivers are largely unknown. This project aims to investigate the mechanisms controlling anterior expansion of the central nervous system, and will generate new knowledge in the areas of nervous system development and evolution. This project aims to impact on our understanding of nervous system function, develop bioinformatics tools with broad utility within the biosciences field, strengthen Australia’s international standing in the developmental neuroscience, and enhance the capacity for interdisciplinary international collaborations.
 +
 +**What is the common factor driving brain overgrowth in autism? Investigating the relationship between epigenetic marks and neural stem cell proliferation (Piper, Thor, Bodén) (The Simons Foundation Autism Research Initiative 2022 Pilot Award; 2022 - 2024)**
 +
 +We will analyze how methylation of H3K36 regulates neural development, with the rationale behind our work being that H3K36 methylation-mediated regulation of NSC proliferation is a central mechanism controlling brain size during development, and that deficits in this process lead to megalencephaly and ASD.
  
 **Dual-function ribonucleases: unexpected agents of antibiotic resistance (with Hugenholtz, Schenk, Soo and Schofield) **Dual-function ribonucleases: unexpected agents of antibiotic resistance (with Hugenholtz, Schenk, Soo and Schofield)
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   * [[research:mikael|Mikael Boden]], Group leader   * [[research:mikael|Mikael Boden]], Group leader
   * [[research:gabe|Gabriel Foley]], Postdoc   * [[research:gabe|Gabriel Foley]], Postdoc
-  * [[Ariane Mora]], PhD student +  * Sanjana Tule, PhD student/Research assistant
-  * [[research:brad|Brad Balderson]], PhD student +
-  * Sanjana Tule, PhD student+
   * [[research:samuel|Sam Davis]], PhD student   * [[research:samuel|Sam Davis]], PhD student
-  * Sorelle Bowman, Master student +  * Oliver Hughes, PhD student 
-  * Anoushka Shah, Master student +  * Zachary Riedlshah, PhD student 
-  * Oliver Hughes, Honours student +  * Ruyi Chen, PhD student 
-  * Hisatake Ishida, Winter research scholar +  * Claire Cheng, visiting 
-  * William Rieger, Research project student+  * Sebastian Porras, Honours student/Research assistant 
 +  * Chongting Zhao, Master student 
 +  * Georgia Wyldbore, Master student 
 +  * Harry Newton, Master student 
 +  * Aishwarya Dhruva, Master student 
 +  * William Rieger, visiting from FU Berlin 
 + 
 +{{:research:bodengroup2023.jpg?500|}} 
 + 
 +//The group anno 2023 (Nov). From left: Linh, Ruyi, Olly, Gabe, Mikael, Sam, Seb, Chongting, Zach, Sanjana// 
 + 
 +{{:research:img_1431.jpg?300|}} 
 + 
 +//The new lab contingent of USA Nov 2023. From left: Ariane, Brad// 
 + 
 +{{:research:group_oct_2023.jpg?500|}} 
 + 
 +//The group anno 2023 (Oct). From left: Gabe, Mikael, Olly, Linh, Seb, Sanjana, Will, Ruyi, Brad// 
 + 
 +{{:research:IMG_2107.jpg?500|}} 
 + 
 +//The group anno 2021. From left: Brad, Ariane, Gabe, Sam, Mikael, Rich. In the background: Phaedra, Kieran//
  
 {{:research:20160701_4200.jpg?500|}} {{:research:20160701_4200.jpg?500|}}
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 ==== Alumni ==== ==== Alumni ====
 +  * Thuy Linh Nguyen, Master student
 +  * [[Ariane Mora]], PhD student, now Postdoc at CalTech [[http://fhalab.caltech.edu/?page_id=1552?page_id=33|Arnold group]]
 +  * [[research:brad|Brad Balderson]], PhD student, now Postdoc at Salk Institute [[https://mcvicker.salk.edu/people.html|McVicker lab]]
 +  * William Rieger, Research assistant, now at FU Berlin
 +  * Sorelle Bowman, Master student
 +  * Anoushka Shah, Master student
 +  * Hisatake Ishida, Winter research scholar
   * [[research:rhys_newell|Rhys Newell]], PhD student (at TRI with Gene Tyson & Ben Woodcroft)   * [[research:rhys_newell|Rhys Newell]], PhD student (at TRI with Gene Tyson & Ben Woodcroft)
   * Diya Prabhuram, Master student   * Diya Prabhuram, Master student
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