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 ==== Funded Projects ====
+**Synergistic industry partnership for bioproduction of platform chemicals
+(Schenk, Bodén, Hine, Guddat, Evans, Ley, Sieber)
+(ARC Linkage Project LP250100335; 2026-2028)**
+Isobutanol is an attractive chemical for the manufacture of a range of products (e.g. rubber, aviation fuels), but has yet to reach competitive yields and pricing. This project integrates the pioneering technique of ancestral sequence reconstruction, in combination with AI, to engineer biocatalysts for the competitive production of isobutanol using both cell-free reaction cascades and fermentative processes. The scalability and commercial impact of both production pathways will be monitored by technoeconomic analyses. This project aims to deliver a rapid pipeline for the design of optimal biocatalysts for sustainable bioproduction processes, will generate valuable IP and contribute to the growth of the aviation fuel industry in Australia.
+**Ancestral Sequence Reconstruction meets protein Language Models
+(Bodén, Rost)
+Queensland Department of Environment and Science 2025-2026**
+The broad objective is to develop and deliver a proof-of-principle framework that “smartly” re-designs nature’s enzymes to produce high-value fine chemicals under industrial conditions; our target enzymatic cascade creates isobutanol from sugar, addressing critical needs in Queensland and Bavaria's biotechnology sectors. We integrate enzyme family-specific insight of Ancestral Sequence Reconstruction with the protein-universe learned by Protein Language Models, enabling the design of novel proteins.
 **Learning from the past to design drugs for the future