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--- research:start [2024/03/17 12:38] – mikael
+++ research:start [2025/02/13 14:30] (current) – mikael
@@ Line 23: / Line 23: @@
 ==== Funded Projects ====
+**Learning from the past to design drugs for the future
+(Schenk, Gumulya, Bodén, Evans)
+(National Health and Medical Research Council 2036797) 2025-2028**
+Bacterial pathogens use a group of enzymes called metallo-β-lactamases (or MBLs) that enable them to be multi-drug resistant. Our project aims to determine how MBLs have evolved from harmless and widespread enzymes, from deep in the past until very recently in response to modern use of antibiotics. These insights will provide valuable functional and structural information that will enable the development of urgently needed strategies to combat β-lactam antibiotic resistance.
+**AI-designing enzymes for the bioeconomy
+(Bodén, Grimm) (Queensland-Bavaria Collaborative Research / Queensland State Government; 2024-2025)**
+This project specifically aims to develop novel strategies for so-called large language models popularised in AI to condition the generation of proteins with desired functions, with a
+focus on combining multiple functionally distinct enzymes into hybrid variants. By bringing together expertise in machine learning, bioinformatics, statistical genetics, and bioeconomy, the project aims to identify different training strategies and prototype AI-methods through collaborative hackathons.
 **TRIAGE: A disease agnostic computational and modelling platform to accelerate variant classification
@@ Line 65: / Line 77: @@
   * [[research:mikael|Mikael Boden]], Group leader
-  * [[research:gabe|Gabriel Foley]], Postdoc
+  * Sanjana Tule, PhD student
-  * Sanjana Tule, PhD student/Research assistant
   * [[research:samuel|Sam Davis]], PhD student
   * Oliver Hughes, PhD student
   * Zachary Riedlshah, PhD student
   * Ruyi Chen, PhD student
-  * Claire Cheng, visiting
+  * Claire Cheng, PhD student
-  * Sebastian Porras, Honours student/Research assistant
+  * Sebastian Porras, PhD student
-  * Chongting Zhao, Master student
+  * William Rieger, PhD student
-  * Georgia Wyldbore, Master student
+  * Chongting Zhao, Master student, volunteer
-  * Harry Newton, Master student
-  * Aishwarya Dhruva, Master student
+{{:research:img_9118.jpg?500|}}
-  * William Rieger, visiting from FU Berlin
+//The group anno 2024 (Nov). From left: Sanjana, Claire, Mikael, Olly, Ariane (visiting from Caltech), Zach, Will, Sam, Ruyi, Gabe//
+{{:research:img_3303.jpg?500|}}
+//The group anno 2024 (Oct). From left: Sanjana, Georgia, Sam, Seb, Mikael, Will, Ruyi, Olly, Chongting, Claire, Gabe//
 {{:research:bodengroup2023.jpg?500|}}
@@ Line 100: / Line 115: @@
 ==== Alumni ====
+  * [[research:gabe|Gabriel Foley]], Postdoc, now Research Fellow at ARC Centre of Excellence in Synthetic Biology, QUT
+  * Georgia Wyldbore, Master student
+  * Harry Newton, Master student
+  * Aishwarya Dhruva, Master student
   * Thuy Linh Nguyen, Master student
   * [[Ariane Mora]], PhD student, now Postdoc at CalTech [[http://fhalab.caltech.edu/?page_id=1552?page_id=33|Arnold group]]