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research:start [2023/11/24 17:14] – mikael | research:start [2025/02/13 14:30] (current) – mikael | ||
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==== Funded Projects ==== | ==== Funded Projects ==== | ||
+ | |||
+ | **Learning from the past to design drugs for the future | ||
+ | (Schenk, Gumulya, Bodén, Evans) | ||
+ | (National Health and Medical Research Council 2036797) 2025-2028** | ||
+ | |||
+ | Bacterial pathogens use a group of enzymes called metallo-β-lactamases (or MBLs) that enable them to be multi-drug resistant. Our project aims to determine how MBLs have evolved from harmless and widespread enzymes, from deep in the past until very recently in response to modern use of antibiotics. These insights will provide valuable functional and structural information that will enable the development of urgently needed strategies to combat β-lactam antibiotic resistance. | ||
+ | |||
+ | **AI-designing enzymes for the bioeconomy | ||
+ | (Bodén, Grimm) (Queensland-Bavaria Collaborative Research / Queensland State Government; 2024-2025)** | ||
+ | |||
+ | This project specifically aims to develop novel strategies for so-called large language models popularised in AI to condition the generation of proteins with desired functions, with a | ||
+ | focus on combining multiple functionally distinct enzymes into hybrid variants. By bringing together expertise in machine learning, bioinformatics, | ||
**TRIAGE: A disease agnostic computational and modelling platform to accelerate variant classification | **TRIAGE: A disease agnostic computational and modelling platform to accelerate variant classification | ||
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* [[research: | * [[research: | ||
- | * [[research: | ||
* Sanjana Tule, PhD student | * Sanjana Tule, PhD student | ||
* [[research: | * [[research: | ||
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* Zachary Riedlshah, PhD student | * Zachary Riedlshah, PhD student | ||
* Ruyi Chen, PhD student | * Ruyi Chen, PhD student | ||
- | * Sebastian Porras, | + | |
- | * Thuy Linh Nguyen, Master | + | |
- | * Chongting Zhao, Master student | + | * William Rieger, PhD student |
+ | * Chongting Zhao, Master student, volunteer | ||
+ | |||
+ | {{: | ||
+ | |||
+ | //The group anno 2024 (Nov). From left: Sanjana, Claire, Mikael, Olly, Ariane (visiting from Caltech), Zach, Will, Sam, Ruyi, Gabe// | ||
+ | {{: | ||
+ | |||
+ | //The group anno 2024 (Oct). From left: Sanjana, Georgia, Sam, Seb, Mikael, Will, Ruyi, Olly, Chongting, Claire, Gabe// | ||
{{: | {{: | ||
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//The group anno 2023 (Nov). From left: Linh, Ruyi, Olly, Gabe, Mikael, Sam, Seb, Chongting, Zach, Sanjana// | //The group anno 2023 (Nov). From left: Linh, Ruyi, Olly, Gabe, Mikael, Sam, Seb, Chongting, Zach, Sanjana// | ||
- | {{ : | + | {{: |
+ | |||
+ | //The new lab contingent of USA Nov 2023. From left: Ariane, Brad// | ||
+ | |||
+ | {{: | ||
//The group anno 2023 (Oct). From left: Gabe, Mikael, Olly, Linh, Seb, Sanjana, Will, Ruyi, Brad// | //The group anno 2023 (Oct). From left: Gabe, Mikael, Olly, Linh, Seb, Sanjana, Will, Ruyi, Brad// | ||
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==== Alumni ==== | ==== Alumni ==== | ||
- | * [[Ariane Mora]], PhD student, now Postdoc at CalTech | + | |
- | * [[research: | + | * Georgia Wyldbore, Master student |
+ | * Harry Newton, Master student | ||
+ | * Aishwarya Dhruva, Master student | ||
+ | * Thuy Linh Nguyen, Master student | ||
+ | | ||
+ | * [[research: | ||
* William Rieger, Research assistant, now at FU Berlin | * William Rieger, Research assistant, now at FU Berlin | ||
* Sorelle Bowman, Master student | * Sorelle Bowman, Master student |