research:mikael_boden

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After finishing a PhD in 1997 at the University of Exeter, UK, I was a postdoctoral research fellow in the School of Computer Science and Electrical Engineering at The University of Queensland. I then held academic positions at the University of Skovde and Halmstad University in Sweden. I re-joined The University of Queensland in 2003. I am currently appointed by the School of Chemistry and Molecular Biosciences, and affiliated with the Institute for Molecular Bioscience.

I am leading a bioinformatics research group, and we are working on a number of research projects, see |here for the official info. Our research aims to develop, investigate and apply bioinformatics methodologies to understand and resolve a range of open problems in genomics, molecular and systems biology. Recent applications involve protein sorting, nuclear protein organisation, mechanisms of transcriptional regulation, sequence and structure determinants of protein function and modification, and protein engineering.

Biological data are now available at scales that challenges our ability to process and analyse them. On the flip side, greater scale gives statistical power to distinguish biologically meaningful signals from mere noise or artefacts, i.e. to identify "drivers" and "determinants" of function and structure. Sometimes the number of features (that describe each observation) is so great that we must use (biological) expertise to constrain the search for signals.

Broadly put, our research aims to

effectively manage the complexity of operations involved in analysing millions of sequence reads, thousands of genomes, and proteomes of thousands of dynamically regulated molecules, etc enable the seamless aggregation (or integration) of uncertain and incomplete data, typical of the next wave of biotechnology, across genomics, proteomics, structural biology, etc, and of using biological expertise empower the interpretation of "whole system" data, aimed at understanding of basis of disease and other scientifically relevant phenotypes, using statistics and machine learning

Over the years we have published papers in journals and conferences and tools (check out citations to my papers). You can contact me at m.boden@uq.edu.au. You can visit me in Molecular Biosciences building (76), level 3 room 330.

My Google Scholar page

Dec 2014, speaking at TU Munich, photo courtesy of Burkhard Rost

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