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| projects [2021/09/20 09:44] – mikael | projects [2021/09/20 17:03] (current) – mikael | ||
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| ==== Research projects with the Boden group ==== | ==== Research projects with the Boden group ==== | ||
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| + | Informal collection of project ideas, at different levels and duration. | ||
| === Phylogenetics, | === Phylogenetics, | ||
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| == Problem: To what extent is epigenetic regulation conserved, and how can evolution help interpret and explain epigenetic regulation? == | == Problem: To what extent is epigenetic regulation conserved, and how can evolution help interpret and explain epigenetic regulation? == | ||
| - | * Approach: The conservation of histone-modifying enzymes is broadly appreciated to exist in many higher species, and is especially relevant to the development of organs. The plan is to probe and model variance | + | * Approach: The conservation of histone-modifying enzymes is broadly appreciated to exist in many higher species, and is especially relevant to the development of organs. The plan is to probe and model variance |
| * Contact: m.boden@uq.edu.au | * Contact: m.boden@uq.edu.au | ||
| * Collaborator: | * Collaborator: | ||
| == Problem: How can we leverage trends of epigenetic marks to highlight regulatory drivers in sparse single-cell and spatial transcriptomes? | == Problem: How can we leverage trends of epigenetic marks to highlight regulatory drivers in sparse single-cell and spatial transcriptomes? | ||
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| * Approach: Evaluate how key histone modifications (collected by ENCODE, say) act coordinately with gene expression; model such coordination with view of predicting epigenetic regulation | * Approach: Evaluate how key histone modifications (collected by ENCODE, say) act coordinately with gene expression; model such coordination with view of predicting epigenetic regulation | ||
| * Contact: m.boden@uq.edu.au | * Contact: m.boden@uq.edu.au | ||
| == Problem: What is the quantitative nature of DNA methylation and its role in cancer? == | == Problem: What is the quantitative nature of DNA methylation and its role in cancer? == | ||
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| * Approach: Data aggregation and careful integration of massive public data sets give rise to new hypotheses. | * Approach: Data aggregation and careful integration of massive public data sets give rise to new hypotheses. | ||
| * Contact: Ariane Mora a.mora@uq.edu.au, | * Contact: Ariane Mora a.mora@uq.edu.au, | ||