Shen S, Werner T, Lukowski SW, Andersen S, Sun Y, Shim WJ, Mizikovsky D, Kobayashi S, Outhwaite J, Chin HS, Chen X, Chapman G, Martin E, Xia D, Pham D, Su Z, Kim D, Yang P, Tan MC, Sinniah E, Zhao Q, Negi S, Redd MA, Powell JE, Dunwoodie SL, Tam P, Bodén M, Ho JWK, Nguyen Q and Palpant NJ. (2025) Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure.
Nature Communications. DOI
10.1038/s41467-025-56533-2 bioRxiv pre-print
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Zhao QY, Shim WJ, Sun Y, Sinniah E, Shen S, Bodén M and Palpant N. (2025) TRIAGE: An R Package for Regulatory Gene Analysis.
Briefings in Bioinformatics. DOI
10.1093/bib/bbaf004
Mora A, Schmidt C, Balderson B, Frezza C and Bodén M. (2024) SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer.
Genome Medicine 16(144). DOI
10.1186/s13073-024-01415-3 Springer Nature SharedIt
Joshi P et al. (2024) Phage Anti-Pycsar Proteins Efficiently Degrade β-Lactam Antibiotics.
Applied Biosciences 3(4). DOI
10.3390/applbiosci3040028
Prabhu A, Tule S, Chuvochina M, Bodén M, McIlroy SJ, Zaugg J and Rinke C. (2024) Machine learning and metagenomics identifies uncharacterized taxa inferred to drive biogeochemical cycles in a subtropical hypereutrophic estuary.
ISME Communications 4(1). DOI
10.1093/ismeco/ycae067
Tule S, Foley G, Zhao C, Forbes M and Bodén M. (2024) Optimal Phylogenetic Reconstruction of Insertion and Deletion Events.
Bioinformatics 40:i277–i286. DOI
10.1093/bioinformatics/btae254
Balderson B, Fane M, Harvey TJ, Piper M, Smith A and Bodén M. (2024) Systematic analysis of the Transcriptional Landscape of Melanoma Reveals Drug-target Expression Plasticity.
Briefings in Functional Genomics elad055. DOI
10.1093/bfgp/elad055
Teshima M, Sutiono S, Döring M, Beer B, Boden M, Schenk G and Sieber V (2023) Development of a Highly Selective NAD+-Dependent Glyceraldehyde Dehydrogenase and its Application in Minimal Cell-Free Enzyme Cascades.
ChemSusChem 17(4). DOI
10.1002/cssc.202301132
Balderson B, Piper M, Thor S and Bodén M. (2023) Cytocipher detects significantly different populations of cells in single cell RNA-seq data.
Bioinformatics. 39(7):btad435. DOI
10.1093/bioinformatics/btad435biorxiv
Sun Y, Shim W, Shen S, Sinniah E, Pham D, Su Z, Mizikovsky D, White MD, Ho JWK, Nguyen Q, Bodén M, Palpant NJ. (2023) Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity.
Nucleic Acids Research. DOI
10.1093/nar/gkad307
Afonso J et al. (2023) Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle.
Biochemistry and Biophysics Reports. DOI
10.1016/j.bbrep.2023.101420
Bayaraa T et al. (2022) Structural and Functional Insight into the Mechanism of the Fe-S Cluster-Dependent Dehydratase from Paralcaligenes ureilyticus.
Chemistry - A European Journal. DOI
10.1002/chem.202203140
Foley G, Mora A, Ross CM, Bottoms S, Sützl L, Lamprecht ML, Zaugg J, Essebier A, Balderson B, Newell R, Thomson RES, Kobe B, Barnard RT, Guddat L, Schenk G, Carsten J, Gumulya Y, Rost B, Haltrich D, Sieber V, Gillam EMJ and Bodén M. (2022) Engineering indel and substitution variants of diverse and ancient enzymes using Graphical Representation of Ancestral Sequence Predictions (GRASP).
PLoS Comput Biol. 18(10): e1010633. DOI
10.1371/journal.pcbi.1010633Pre-print
Lv Y, Zheng S, Goldenzweig A, Liu F, Gao Y, Yang X, Kandale A, McGeary RP, Williams S, Kobe B, Schembri MA, Landsberg MJ, Wu B, Brück TB, Sieber V, Bodén M, Rao Z, Fleishman SJ, Schenk G and Guddat LW. (2022) Enhancing the Thermal and Kinetic Stability of Ketol-Acid Reductoisomerase, a Central Catalyst of a Cell-Free Enzyme Cascade for the Manufacture of Platform Chemicals.
Applied Biosciences. 1(2):163-178. DOI
10.3390/applbiosci1020011
Harris KL, Thomson RES et al. (2022) Ancestral sequence reconstruction of a cytochrome P450 family involved in chemical defence reveals the functional evolution of a promiscuous, xenobiotic-metabolizing enzyme in vertebrates.
Molecular Biology and Evolution. DOI
10.1093/molbev/msac116
Mora A, Rakar J, Monedero-Cobeta I, Yaghmaeian-Salmani B, Starkenberg A, Thor S, Bodén M. (2022) Variational autoencoding of gene landscapes during mouse CNS development uncovers layered roles of Polycomb Repressor Complex 2.
Nucleic Acids Research. 50(3):1280–1296. DOI
10.1093/nar/gkac006 Pre-print in bioRxiv
Yaghmaeian-Salmani B, Balderson B, Bauer S, Ekman H, Starkenberg A, Perlmann T, Piper M, Bodén M, Thor S. (2022) Selective Requirement for Polycomb Repressor Complex 2 in the Generation of Specific Hypothalamic Neuronal Sub-types.
Development. 149(5):dev200076. DOI
10.1242/dev.200076 Pre-print in bioRxiv
Ross CM, Foley G, Bodén M, Gillam EMJ. (2022) Using the Evolutionary History of Proteins to Engineer Insertion-Deletion Mutants from Robust, Ancestral Templates Using Graphical Representation of Ancestral Sequence Predictions (GRASP).
Methods Molecular Biology. 2397:85-110. DOI
10.1007/978-1-0716-1826-4_6.
Wilson L et al. (2021) Kinetic and Structural Characterization of the First B3 Metallo-β-Lactamase with an Active Site Glutamic Acid.
Antimicrobial Agents and Chemotherapy. 65(10):e0093621. DOI
10.1128/AAC.00936-21.
Kojic M et al. (2021) Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype.
Nature Communications. 12:2678. DOI
10.1038/s41467-021-22888-5
Newell R, Pienaar R, Balderson B, Piper M, Essebier A and Bodén M (2021) ChIP-R: Assembling reproducible sets of ChIP-seq and ATAC-seq peaks from multiple replicates.
Genomics. 113(4). DOI
10.1016/j.ygeno.2021.04.026 Pre-print in bioRxiv
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Lai JS, Rost B, Kobe B and Bodén M (2020) Evolutionary model of protein secondary structure capable of revealing new biological relationships.
Proteins. 88(9):1251-1259. DOI
10.1002/PROT.25898Pre-print
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Fraser JA, et al. (2020) Common regulatory targets of NFIA, NFIX and NFIB during postnatal cerebellar development.
The Cerebellum. 19:89–101. DOI
10.1007/s12311-019-01089-3
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Foley G, Sützl L, D'Cunha SA, Gillam EMJ and Bodén M (2019). SeqScrub: A web tool for automatic cleaning and annotation of FASTA file headers for bioinformatic applications.
Biotechniques. 67(2). DOI
10.2144/btn-2018-0188
Littmann M, Goldberg T, Seitz S, Bodén M and Rost B (2019). Detailed prediction of protein sub-nuclear localization.
BMC Bioinformatics. 20(1):205. DOI
10.1186/s12859-019-2790-9
Sützl L, Foley G, Gillam EM, Bodén M and Haltrich D (2019). The GMC family of oxidoreductases revisited: analysis and evolution of fungal GMC oxidoreductases.
Biotechnology for Biofuels. 12:118. DOI
10.1186/s13068-019-1457-0
Fraser J, Essebier A, Brown A, Ayala Davila R, Sengar A, Tu A, Ensbey K, Day B, Scott M, Gronostajski R, Wainwright B, Bodén M, Harvey T and Piper M. (2019) Granule neuron precursor cell proliferation is regulated by NFIX and intersectin 1 during postnatal cerebellar development.
Brain Structure and Function. 224:2, pp 811–827. DOI
10.1007/s00429-018-1801-3
Gumulya Y, et al. (2019) Engineering thermostable CYP2D enzymes for biocatalysis using combinatorial libraries of ancestors for directed evolution (CLADE).
ChemCatChem. 11:2, pp 841-850. DOI
10.1002/cctc.201801644
Gumulya Y, et al. (2018) Engineering highly functional thermostable proteins using ancestral sequence reconstruction.
Nature Catalysis. 1, pp 878–888. DOI
10.1038/s41929-018-0159-5 Free access
Fletcher SJ, Bodén M, Mitter N and Carroll BJ (2018) SCRAM: a pipeline for fast index-free small RNA read alignment and visualization.
Bioinformatics. 34:15, pp 2670–2672. DOI
10.1093/bioinformatics/bty161Free access
Zaugg J, Gumulya Y, Bodén M, Mark AE and Malde AK (2018) Effect of Binding on Enantioselectivity of Epoxide Hydrolase.
Chem Inf Model. 58 (3): 630–640. DOI
10.1021/acs.jcim.7b00353.
Zaugg J, Gumulya Y, Malde AK and Bodén M (2017) Learning Epistatic Interactions from Sequence-Activity Data to Predict Enantioselectivity.
J Comput Aided Mol Des. 31(12):1085–1096. DOI
10.1007/s10822-017-0090-x Free access
Essebier A, Lamprecht M, Piper M and Bodén M (2017) Bioinformatics approaches to predict target genes from transcription factor binding data.
Methods. Volume 131, Pages 111-119. DOI
10.1016/j.ymeth.2017.09.001.
Bernhofer M, Goldberg T, Wolf S, Ahmed M, Zaugg J, Bodén M and Rost B (2017) NLSdb - major update for database of nuclear localization signals and nuclear export signals,
Nucleic Acids Res. 46:D1, pp D503–D508. DOI
10.1093/nar/gkx1021
Patrick R, Kobe B, Le Cao KA and Bodén M (2017) PhosphoPICK-SNP: Quantifying the effect of amino acid variants on protein phosphorylation,
Bioinformatics. 33 (12): 1773-1781. DOI
10.1093/bioinformatics/btx072.
Free access
O'Connor TR, Bodén M and Bailey, TL (2017) CISMAPPER: predicting regulatory interactions from transcription factor ChIP-seq data.
Nucleic Acids Res 45 (4): e19. DOI:
10.1093/nar/gkw956.
Williams SJ, Yin L, Foley G, Casey LW, Outram MA, Ericsson DJ, Lu J, Bodén M, Dry I and Kobe B (2016) Structure and function of the TIR domain from the grape NLR protein RPV1.
Frontiers in Plant Science. DOI:
10.3389/fpls.2016.01850
Fraser J, Essebier A, Gronostajski RM, Bodén M, Wainwright BJ, Harvey TJ and Piper M (2016) Cell type-specific expression of NFIX in the developing and adult cerebellum.
Brain Structure and Function. 222:5, pp 2251–2270. DOI:
10.1007/s00429-016-1340-8
Patrick R, Horin C, Kobe B, Le Cao KA and Bodén M (2016) Prediction of kinase-specific phosphorylation sites through an integrative model of protein context and sequence. BBA -
Proteins and Proteomics. 1864(11):1599-608. DOI:
10.1016/j.bbapap.2016.08.001.
Essebier A, Vera Wolf P, Cao MD, Carroll BJ, Balasubramanian S and Bodén M (2016) Statistical enrichment of epigenetic states around triplet repeats that undergo expansions.
Frontiers in Neuroscience. 10:92. DOI:
10.3389/fnins.2016.00092 (Open access)
Cao MD, Allison L, Dix TI and Bodén M (2016) Robust Estimation of Evolutionary Distances with Information Theory.
Molecular Biology and Evolution. 33 (5): 1349-1357. DOI:
10.1093/molbev/msw019
Huang W, Johnston W, Bodén M and Gillam EM (2016) ReX - A suite of computational tools for the design, visualization and analysis of chimeric protein libraries.
BioTechniques. Vol. 60, No. 2, pp. 91–94. DOI:
10.2144/000114381.
Oyarzun P, Ellis JJ, Gonzalez-Galarza FF, Jones AR, Middleton D, Bodén M and Kobe B (2015) A bioinformatics tool for epitope-based vaccine design that accounts for human ethnic diversity: Application to emerging infectious diseases.
Vaccine. 33(10):1267-73. DOI:
10.1016/j.vaccine.2015.01.040
Patrick R, Le Cao KA, Kobe B and Bodén M (2015) PhosphoPICK: Modelling cellular context to map kinase-substrate phosphorylation events.
Bioinformatics. 31(3):382-389. DOI:
10.1093/bioinformatics/btu663
Cao MD, Balasubramanian S and Bodén M (2015) Sequencing technologies and tools for short tandem repeat variation detection,
Briefings in Bioinformatics. 16 (2): 193-204. DOI:
10.1093/bib/bbu001.
Rona G, Borsos M, Ellis J, Mehdi A, Christie M, Kornyei Z, Neubrandt M, Toth J, Bozoky Z, Buday L, Madarasz E, Bodén M, Kobe B and Vertessy B (2014). Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation.
Cell Cycle. 13(22). DOI:
10.4161/15384101.2014.960740 (author eprint)
Mehdi AM, Patrick R, Bailey TL and Bodén M (2014) Predicting the dynamics of protein abundance,
Molecular & Cellular Proteomics. May;13(5):1330-40. DOI:
10.1074/mcp.M113.033076.
Cao MD, Tasker E, Willadsen K, Imelfort M, Vishwanathan S, Sureshkumar S, Balasubramanian S and Bodén M (2014)
Inferring Short Tandem Repeat Variation from Paired-End Short Reads, Nucleic Acids Research. Feb;42(3):e16. DOI:
10.1093/nar/gkt1313.
Mazgut J, Tino P, Bodén M and Yan H (2014)
Dimensionality Reduction and Topographic Mapping of Binary Tensors, Pattern Analysis and Applications. 17(3):497-515. DOI:
10.1007/s10044-013-0317-y.
Chang C-W, Counago RLM, Williams S, Bodén M and Kobe B (2013) The distribution of different classes of nuclear localization signals (NLSs) in different organisms and the utilization of the minor NLS-binding site in plant nuclear import factor importin-alpha,
Plant Signaling & Behavior, 8(10). DOI:
10.4161/psb.25976.
Chang C-W, Counago RLM, Williams S, Bodén M and Kobe B (2013)
Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-alpha, Traffic. Nov;14(11):1144-54. DOI:
10.1111/tra.12098
Oyarzun P, Ellis JJ, Bodén M and Kobe B (2013) PREDIVAC:
CD4+ T-cell epitope prediction for vaccine design that covers 95% of human HLA class II DR protein diversity, BMC Bioinformatics, 14:52. DOI:
10.1186/1471-2105-14-52
Willadsen K, Cao MD, Wiles J, Balasubramanian SK and Bodén M (2013)
Repeat-encoded poly-Q tracts show statistical commonalities across species, BMC Genomics 14:76. DOI:
10.1186/1471-2164-14-76
Mehdi A, Sehgal S, Kobe B, Bailey TL and Bodén M (2013) DLocalMotif:
A discriminative approach for discovering local motifs in protein sequences, Bioinformatics, 29(1):39-46. DOI:
10.1093/bioinformatics/bts654.
Chang C-W, Counago RLM, Williams S, Bodén M and Kobe B (2012)
Crystal Structure of Rice Importin-alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals, The Plant Cell, 24(12):5074-88. doi:
10.1105/tpc.112.104422. (Access)
Patrick R, Le Cao K-A, Davis M, Kobe B and Bodén M (2012) Mapping the stabilome: a novel computational method for classifying metabolic protein stability. BMC Systems Biol 6(1):60. (Open access.)
Kobe B & Bodén M (2012) Computational modelling of linear motif-mediated protein interactions. Curr Top Med Chem. 12 (14), 1553-1561 [PMID: 22827524]
Willadsen K, Mohamad N, and Bodén M (2012) NSort/DB: An intra-nuclear compartment protein database.
Genomics, Proteomics & Bioinformatics 10(4):226-229. DOI:
10.1016/j.gpb.2012.07.001
Madala PK, Fairlie DP and Bodén M (2012) Matching cavities in G protein-coupled receptors to infer ligand-binding sites. Journal of Chemical Information & Modeling. 52(5):1401-10.
Bauer DC, Willadsen K, Buske FA, Le Cao K-A, Bailey TL, Dellaire G and Bodén M (2011) Sorting the nuclear proteome. Bioinformatics. 27(13):i7-14. (Open access.)
Mehdi A, Sehgal S, Kobe B, Bailey TL and Bodén M (2011) A probabilistic model of nuclear import of proteins. Bioinformatics. 27(9):1239-46.
Marfori M, Mynott A, Ellis JJ, Mehdi AM, Saunders NF, Curmi PM, Forwood JK, Bodén M and Kobe B (2011) Molecular basis for specificity of nuclear import and prediction of nuclear localization. Biochim Biophys Acta 1813(9):1562-77.
You L, Brusic VL, Gallagher M and Bodén M (2010) Using Gaussian process with test rejection to detect T-cell epitopes in pathogen genomes. IEEE/ACM Trans Comp Biol Bioinformatics 7(4):741-751.
Mohamad N and Bodén M (2010) The proteins of intra-nuclear bodies: a data-driven analysis of sequence, interaction and expression. BMC Systems Biology 4:44. (Open access.)
Buske FA, Bodén M, Bauer DC and Bailey TL (2010) Assigning roles to DNA regulatory motifs using comparative genomics. Bioinformatics 26:860-6. (Open access.)
Bauer DC, Buske FA, Bailey TL and Bodén M (2010) Predicting SUMOylation sites in developmental transcription factors of Drosophila melanogaster. Neurocomputing. 73(13-15): 2300-2307.
Bodén M, Dellaire G, Burrage K and Bailey TL (2010) A Bayesian network model of proteins' association with Promyelocytic leukemia (PML) nuclear bodies. J Comp Biol 17(4): 617-30.
Bailey T, Bodén M, Whitington T and Machanick P (2010) The value of position-specific priors in motif discovery using MEME. BMC Bioinformatics 11:179. (Open access.)
Buske FA, Maetschke S and Bodén M (2009) It's about time: signal recognition in staged models of protein translocation. Pattern Recognit 42(4): 567-574.
Buske FA, Thier R, Gillam EM and Bodén M (2009) In silico characterisation of protein chimeras: relating sequence and function within the same fold. Proteins 77(1), pp. 111-120.
Bailey TL, Bodén M, Buske FA, Frith M, Grant CE, Clementi L, Ren J, Li WW and Noble WS (2009) MEME Suite: tools for motif discovery and searching. Nucleic Acids Res 37:W202-8. (Open access.)
Bodén M and Teasdale RD (2008) Determining nucleolar association from sequence by leveraging protein-protein interactions. J Comp Biol 15(3): 291-304.
Bodén M and Bailey TL (2008) Associating transcription factor binding site motifs with target GO terms and target genes. Nucleic Acids Res 36(12): 4108-4117. (Open access.)
Bodén M and Bodén M (2007) Evolving spelling exercises to suit individual student needs. Appl Soft Comput 7: 126-135.
Suksawatchon J, Lursinsap C and Bodén M (2007) Computing the reversal distance between genomes in the presence of multi-gene families via binary integer programming. J Bioinformatics Comp Biol 5(1): 117-133.
Hawkins J, Mahony D, Maetschke S, Wakabayashi M, Teasdale RD and Bodén M (2007) Identifying novel peroxisomal proteins. Proteins 69(3): 606-616.
Hawkins J, Davis L and Bodén M (2007) Predicting nuclear localization. J Proteome Res 6(4): 1402-1409.
Bauer D, Bodén M, Thier R and Gillam EM. STAR: Predicting recombination sites from amino acid sequence. BMC Bioinformatics, 7:437, 2006. (Open access.)
Bodén M and Bailey TL. Identifying sequence regions undergoing conformational change via predicted continuum secondary structure. Bioinformatics. 22(15): 1809-1814, 2006. (Open access.)
Bodén M, Yuan Z and Bailey TL. Prediction of protein continuum secondary structure with probabilistic models based on NMR solved structures. BMC Bioinformatics. 7:68, 2006. (Open access.)
Yuan Z, Zhang F, Davis MJ, Bodén M and Teasdale RD. Predicting the solvent accessibility of transmembrane residues from protein sequence. Journal of Proteome Research. 5(5):1063-1070, 2006.
Hawkins J and Bodén M. Detecting and sorting targeting peptides with recurrent networks and support vector machines. Journal of Bioinformatics and Computational Biology, 4(1), 2006.
Bodén M and Hawkins J. Prediction of subcellular localisation using sequence-biased recurrent networks. Bioinformatics. 21(10):2279-2286, 2005.
Hawkins J and Bodén M. The applicability of recurrent neural networks for biological sequence analysis. IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2(3): 243-253, 2005.
Bodén M and Hawkins J. Improved access to sequential motifs: A note on the architectural bias of recurrent networks. IEEE Transactions on Neural Networks. 16(2), 2005.
Bodén M. Generalization by symbolic abstraction in cascaded recurrent networks, Neurocomputing, 57, pp. 87-104, 2004.
Bodén M and Blair A. Learning the dynamics of embedded clauses, Applied Intelligence: Special issue on natural language and machine learning, 19(1/2), pp. 51-63, 2003.
Bodén M and Wiles J. On learning context free and context sensitive languages, IEEE Transactions on Neural Networks. 13(2), pp. 491-493, 2002.
Bodén M and Wiles J. Context-free and context-sensitive dynamics in recurrent neural networks, Connection Science, 12 (3/4), pp. 197-210, 2000.
Bodén M and Niklasson L. Semantic systematicity and context in connectionist Networks, Connection Science, 12 (2), pp. 111-142, 2000.