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 The human genome is packaged into chromatin and assembled into 3D self-interacting chromatin domains that regulate gene expression and coordinate the process of DNA replication. Understanding the relationships between genome structure and function is one of the outstanding challenges in modern biology. Changes in the 3D structure of the genome can cause copying errors (genetic mutations) during DNA replication that results in diseases such as cancer and advanced aging. Decoding the relationships between the genomic landscape and cellular processes such as DNA replication has the potential to inform the development of novel treatments that can treat cancer and extend longevity.
-In this project we are seeking talented and enthusiastic postgraduate students to tackle two fundamental questions: 1. How does the epigenome and the 3D organisation of the genome regulate DNA replication? 2. How are these processes disrupted in cancer and impacted by cancer therapies. The project will assess the impact of genomic features on replication using nanopore sequencing data generated by the Jones lab’s and their artificial intelligence assay for assessing DNA replication in human cells (doi: https://doi.org/10.1101/2022.09.22.509021) and publicly available Hi-C, Repli-Seq, CUT & RUN, ChIP-seq, scSeq, datasets (e.g., GEO, ENCODE).
+In this project we are seeking talented and enthusiastic postgraduate students to tackle two fundamental questions: 1. How does the epigenome and the 3D organisation of the genome regulate DNA replication? 2. How are these processes disrupted in cancer and impacted by cancer therapies. The project will assess the impact of genomic features on replication using nanopore sequencing data generated by the Jones lab’s and their artificial intelligence assay for assessing DNA replication in human cells (https://doi.org/10.1101/2022.09.22.509021) and publicly available Hi-C, Repli-Seq, CUT & RUN, ChIP-seq, scSeq, datasets (e.g., GEO, ENCODE).
 Bioinformatics and Computer Science students with skills in R, Python and C++ that are familiar with software suites for the comparison, manipulation and annotation of genomic features are encouraged to contact Dr Mathew Jones (mathew.jones@uq.edu.au) to learn more about the projects available.